Dipropos – what is it used for?
Diprophos is a corticosteroid preparation that is used to treat various inflammatory and allergic conditions.
It is a suspension for intramuscular or local injection containing Betamethasone in two forms, each of which serves a different purpose:
- betamethasone dipropionate (betamethasone dipropionate) – a long-acting corticosteroid that provides a long-lasting anti-inflammatory effect
- betamethasone sodium phosphate (betamethasone sodium phosphate) – a fast-acting corticosteroid that provides rapid relief of acute symptoms.
This combination of betamethasone esters with varying degrees of solubility (fast-acting fraction and depot fraction) works to reduce inflammation, suppress the immune system, and relieve symptoms associated with various conditions. This dual-action formula allows for both immediate and long-lasting relief, making it suitable for both acute and chronic conditions.
Diprophos injection suspension is available in ampoules of 1 ml of 1 and 5 pieces in a package.
Mechanism of action
The preparation has a powerful anti-inflammatory, anti-rheumatic, anti-allergic and immunosuppressive effect.
It stimulates the biosynthesis of proteins inhibiting phospholipase A2, as a result of which it suppresses the metabolism of arachidonic acid.
Diprophos is injected intramuscularly or locally – intra-articular, peri-articular, intralesional. It is dosed individually according to the specific disease, its severity and the impact on the patient. The doctor designs a treatment plan to achieve the best therapeutic results while minimizing potential side effects.
After long-term treatment with Diprofos, the intake is stopped as the dose is gradually reduced.
What is Diprofos used for?
Diprophos is used in the treatment of many serious diseases due to its anti-inflammatory and immunosuppressive properties.
The main indications for application are:
Rheumatic diseases
- rheumatoid arthritis – in the absence of effect from other drugs, Diprofos is used for short-term treatment of rheumatoid arthritis. The goal is to influence the acute episode.
- osteoarthritis – intra-articular injection of Diprophos relieves pain and stiffness in the joint after 2 to 4 hours.
- bursitis – is applied short-term as adjunctive therapy in order to control the exacerbation. Intrabursal injection in acute bursitis leads to pain relief and restoration of range of motion in the joint for several hours.
- ankylosing spondylitis
- acute attack of gout
- radiculitis
- epicondylitis
- coccidinia
- torticollis
- lumbago
- exostosis
- fasciitis, etc.
Allergic diseases
- chronic bronchial asthma
- asthmatic status
- angioedema
- severe form of hay fever
- allergic rhinitis
- acute allergic bronchitis
- serum sickness
- insect bites
- Drug allergy.
Dermatological diseases
- atopic dermatitis
- neurodermatitis
- contact dermatitis
- urticaria
- hypertrophic lichen planus
- alopecia areata
- psoriasis
- pemphigus
- keloids
- dermatitis herpetiformis
- cystic acne.
Collagenoses
In case of deterioration or as a maintenance therapy, Diprofos can be used in:
- lupus erythematosus
- scleroderma
- dermatomyositis
- periarteritis nodosa.
Other indications for the use of Diprofos
- in leukemia and lymphomas in adults, in acute leukemia in children as a palliative agent
- ulcerative colitis, Crohn’s disease
- nephrotic syndrome
- adrenogenital syndrome, etc.
Taking high doses of Dipropos or long-term treatment may cause side effects in some patients. Side effects are similar to those of all corticosteroids.
